We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! Omnitrope/HGH pricing and protocol question? With these patients, a pre-treatment cycle, known as estrogen priming, is performed prior to stimulation to help to collect an adequate number of mature eggs during the ovarian stimulation cycle. Find advice, support and good company (and some stuff just for fun). All rights reserved. Infertility Support Community in Partnership with RESOLVE. Of course, during a regular cycle most women naturally produce only a single mature egg. I tried it and it seemed to help with even follicle growth but so some reason I had less eggs in the follicles than prior cycle when I was on bcp first? So it's a low dose of Lupron, but not necessarily low doses of stims overall. Beta 1117 However other had mature egg and we did Icsi by it didn't grow from there. The hypothesis is that if we treat patients prior to starting their IVF cycle with estrogens ( the estrogen priming protocol) or androgens ( such as DHEA) , they will produce more eggs because more follicles will be recruited when we start the superovulation . I never hoped so I never even asked that question. I started my estrace this morning and feel a little icky so far. I am on my first round of IVF (hopefully last!). I did EPP with my 3rd cycle and it didn't help. I have AMH of 0.1 or something like that. 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN For this reason, the antagonist protocol is a good option for those women most susceptible to OHSS. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. On CD2 I started 300 Gonal F and 150 Menopur. I hope a tweak of the protocol will help or maybe it was just an off cycle for me. My second included BCP before stimulating and I didnt stimulate well. BFP October 22!!!! This comes from a 38,000 patient European registry. We are OOP as well. It's a sort of "slow burn" methodology the hope being that they slow you way down and protect egg quality while allowing you to stim longer. Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. I was on the highest dosage of Gonal with that cycle. MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). Some clinics use EPP more than others. That patients must use an hCG trigger they cannot use Lupron as a trigger (because theyre already taking it) which is problematic because Lupron is the only trigger shot that fends off OHSS. - Longdom I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. I'm not sure what your stats are, but Check seems to have had some good success with women over 40 who have high FSH, so I'd say go with him. That could be why they are decreasing your Follistim too. Cool.let me know what he says if you would please. Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. Dr Sher says "oestrogen priming of FSH receptors has been reported to slow premature follicular development and to promote granulosa cell FSH receptor induction". I also did ganirelix during this time. it's 1 week since last patch. I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). I will have retrieval hopefully this weekend and will let you know what happens. Anyone with very low AMH do the estrogen priming and have a good response? I was on BCP for 15 years and when I went off them I never got my period. However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. Are you wanting to learn more about the IVF process? I started taking 4mg of estrace on cd 21. By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use and Privacy Policy. (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. The stim phase was just like a usual antagonist cycle. As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. Also, your stims are actually a lot higher than most REs will do for DOR. 2nd IVF/ICSI age 42 : Menopur 425; 2 eggs; 2 fertislised; transfer day 5; BFN EPP results: 17 retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 have been biopised. BabyCenter may earn a commission from shopping links. i had success with DE. After 2 years, tons of tests and 5 IVF cycles, it still feels unreal.Estrogen Priming protocol does not have birth control pills. Estrogen priming is pretty standard for over 40. Twins & Multiples: Your Tentative Time Table. Anyhow, do you know how what they wanted the priming to do? Ugh, that made me feel like I was hit by a truck. my RE is going back to the drawing board for my final IVF. Often two other types of drugs are needed to accompany gonadotropin: those that block eggs from maturing and being ovulated before they can be retrieved, and those that help trigger the eggs to mature so they can be retrieved. I used two patches a dayandchanged the patches every third day. However, that information will still be included in details such as numbers of replies. I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. For free! Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. Many REs swear by this for DOR. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. Surprise spontaneous just 7 months postpartum while still breastfeeding!!! Back to home page. I sounds like a good plan since the first protocol didn't work out so great. Thanks for sharing your story. New doctor recommended EPP to promote more even follicle growth. Several functions may not work. Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . The #1 app for tracking pregnancy and baby growth. I was at the max stim dose to get the response I did. Julie, will be KMFX for you and those embryos! Interesting that they are only putting you on it for 7 days.. Thanks so much in advance! Natural cycle is no meds to stim so u get 1 egg at best. Went to retrieval anyway, did ICSI, but it didn't fertilize. This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. IVF#3 September 2009 - cancelled - poor response A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. In the next section well walk you through the mechanics of each protocol. Only 2 drugs during stim and finally got one good pgs tested embryo!!! BFP oct 16th!!! After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. An analysis that combined six extremely small studies (that in aggregate only included about 160 patients) show gains in live birth rates, as you can see below. I went to a UK FSH friendly (thank you joy for the recommendation) clinic for a consultation. Candice maybe11 129 Dec 08, 2009 #3 Hi, IVF#1 with ICSI spring 2006 - 3 eggs retrieved, one transferred - BFN My doc started me on estrogen patch, one patch changing every 3 days until my period for 5 days and I just took it off and will be takingClomiphene after a day of taking off the patch, then after a day start stim. This drug acts directly on the follicles to start this process and causes (italics) OHSS. Are you sure you want to block this member? I am planning on doing 2-3 cycles with banking and then CCS testing due to previous miscarriages. Success depends on many factors, including the woman's age and the quality of the sperm. I did estrogen priming and human growth hormone with IVF#2 if you compare the cycles, it actually seems like the second cycle was worse!! Can you try to conceive the cycle that you estrogen prime? Sign up now for your monthly dose of fertility info, experiences, and insight. Is estrogen priming the same thing as using BCPs to suppress? Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! More than I wanted, I think! There are 2 - 3 core protocols: the Long Agonist, Antagonist and Flare. After it happens, I keep receiving bills in the mail. Just devastated with my results today so just want to cry it out and then I will respond to you. Dont know what. Below is data collected on over 3,000 cycles for each protocol approach in the Netherlands. I am only 28 with normal amh/fsh levels so we were pretty shocked and upset when we only had a couple embryos on day 3 and then nothing to freeze. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. I was long Lupron and that one was cancelled because my precious RE only saw very few follies. What affect did the epp have on your follicles? I'm starting with this IUI and then will see how I respond and move forward from there. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. I had success with EPP after failing with other protocols. I would ask your doctor, but I guess you just do nothing while preparing for the cycle. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). Hi there. After my period started, my doctor kept me on the patches for five more days. Use of this site is subject to our terms of use and privacy policy. I was not informed of this ahead of timeand was pretty upset that that they threw away something that might have had a chance. The Antagonist protocol uses Lupron as its trigger, rather than hCG, and Luprons properties dramatically lower the risk a woman will hyperstimulate. Do they use this protocol as sort of standard for someone who is starting? Anyhoo, I am just curious whose done this and what the difference was in terms of their egg numbers and quality.especially if anyone used it for quality. IVF#2 started sept 19th He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. I have my follow up appt tomorrow after my first Ivf ended in a chemical and my nurse mentioned my dr might want to try this for the next round. As you can see in our summary below, there are multiple drugs that can perform these two functions the one thats chosen dictates the protocol strategy. Protocol as sort of standard for someone who is starting RE decided to start on! 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