Science can improve health and well-being in so many ways, from the development of everyday healthcare products to medicines and vaccines. Once-Daily Single-Inhaler Versus Twice-Daily Multiple-Inhaler Triple Therapy: Two Replicate Trials in Patients With Chronic Obstructive Pulmonary Disease (COPD). Registered in England and Wales No. 4. Targeting the DNA damage response in cancer. Preliminary Safety, Efficacy, and Pharmacokinetic/Pharmacodynamic Characterization from GARNET, a Phase 1/2 Clinical Trial of the Anti PD 1 Monoclonal Antibody, Dostarlimab, in Patients with Recurrent or Advanced MSI H and MSS Endometrial Cancer (EC), For a copy of a poster please call 1-877-475-6448, 1. Jacob, Tanzania Communication and Development Centre, The race against malaria: handing the baton to the next generation, Giving mothers and babies a healthier start, Work experience, placements and internships, GSK actions to support the global response to COVID-19, COVID-19 prompts increased focus on self-care, GSK Study Register and patient level data, “Pull” the Science: 2020 Antimicrobial Resistance Benchmark. [Poster No. 11. 2. Niraparib Exposure-Response Relationship in Patients (pts) with Newly Diagnosed Advanced Ovarian Cancer (AOC), 3. Open-label, single-arm study evaluating the antitumor activity and safety of niraparib as neoadjuvant treatment in patients with localized, HER2-negative, BRCA-mutant breast cancer, 1. REF—US0000604 Meningococcal Vaccination Among Patients Newly Diagnosed at High-Risk For Meningococcal Disease in the US, 1. 1053; Abstract A5058]. Molfino NA, Averell CM, Hahn BA, et al. Immunol Rev. Zejula can cause fetal harm and females of reproductive potential should use effective contraception. Comparison of Peak Inspiratory Flow Rate Between Clinical Trial and Real-World Populations. A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia, 2. Responsible business is how we do business. 1-800-822-7967. Pharmacokinetics and Safety Following a Single Oral Dose of Niraparib in Patients with Moderate Hepatic Impairment, 5. Current real-world treatment patterns and outcomes in patients with relapsed/refractory multiple myeloma, 2. [Poster No. PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes. NY-ESO-1 and LAGE1A – an emerging target for cell therapies in solid tumours, 8. GSK Products Leaving GSK Pro You are leaving GSK Pro to visit a separate website not associated with GSK Pro, a portal for US Healthcare Professionals.There are website links to third-party sites on GSK Pro. Phase 2, Multi Arm Study of Niraparib in Combination With a PD 1 Inhibitor in Patients With Non Small Cell Lung Cancer: JASPER, 1. Relapsed/Refractory Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML), Solid Tumors and Non-Hodgkin's Lymphoma (NHL), Relapsed/Refractory Solid Tumors and Diffuse Large B-Cell Lymphoma (DLBCL). Rapoport AP, Stadtmauer EA, Binder-Scholl GK, et al. P699; Abstract A1814]. A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia, 2. Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss. P805; Abstract A7742]. Information and tools for investors including share and dividend information, share price analysis, latest news and corporate reporting, Discover our latest financial performance announcement and search for historical quarterly results materials, Explore the latest news, different ways to stay in touch and available useful resources, Keep up to date with our news and recent announcements. Future Oncol. Kelley MR, Logsdon D, Fishel ML. Curr Opin Pharmacol. Mafodotin delivered to BCMA-expressing malignant cells inhibits microtubule polymerization, resulting in immune-independent apoptosis that is accompanied by release of markers of immunogenic cell death (ICD), which may contribute to an adaptive immune response. Characterization of severe asthma patients affiliated to the Hospital Italiano Medical Care Program in Buenos Aires, Argentina. ongoing research for GSK’s key products, This information is intended for healthcare professionals only. Monitor complete blood counts to detect hematologic adverse reactions, as well as to detect cardiovascular disorders, during treatment. Comparison of Peak Inspiratory Flow Rate Between Clinical Trial and Real-World Populations. Das M, Zhu C, Kuchroo VK. [Poster No. DREAMM-6: Safety and Tolerability of Belantamab Mafodotin in Combination with Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma (RRMM). By clicking this link, you will be taken to a website that is independent from GSK. Efficacy of Umeclidinium/Vilanterol Versus Umeclidinium or Salmeterol: A Number-Needed-to-Treat Analysis of the EMAX Trial. 2017;12(5):323-339. GSK is investigating the activity of two compounds that target protein arginine methyltransferases (PRMTs). Asthma Control in Patients With Severe Eosinophilic Asthma Treated With Mepolizumab in Real-Life Settings: The Prospective, REALITI-A Study. PLoS Genet. You are about to leave a GSK website. 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