If mortalities occur, a full study should be conducted. EPA works closely with other government agencies and with other countries through the OECD to facilitate the harmonization of test guidelines. As of October 2007, five test guidelines and three guidance documents have been published by OECD, with an additional two guidelines expected to be published later in 2007. Note that where data will be required under a TSCA rule (such as a test rule under TSCA section 4), EPA may promulgate a TSCA-specific version of the applicable guideline as a rule. �t����a@@!���&�"�& C.4.5 OECD TG 407: Repeated Dose 28 Day Oral Toxicity Study in Rodents 295 C.4.6 OECD TG 416: Two-Generation Reproduction Toxicity Study (including TG 415: One-Generation Reproduction Toxicity Study) 311 Annex 1. When changes to a guideline are not significant, EPA will not subject the revision to external peer review before the revised guideline is published as part of this library. Test guidelines used in regulatory actions as bases for test standards under TSCA are typically promulgated in 40 CFR part 799, or may be written into specific TSCA rules (such as test rules under TSCA section 4). endobj OECD GUIDELINES FOR THE TESTING OF CHEMICALS Honeybees, Acute Oral Toxicity Test INTRODUCTION 1. OECD Guidelines for the Testing of Chemicals • The OECD Guidelines are a unique tool for assessing the potential effects of chemicals on human health and the environment • Accepted internationally as standard methods for safety testing 7. United States Environmental Protection Agency, Test Guidelines for Pesticides and Toxic Substances, test guidelines established by the Organization for Economic Cooperation and Development (OECD), U.S. Interagency Coordinating Committee for the Validation of Alternative Methods, harmonize pesticide residue chemistry test guidelines. MISSION Mission of the organization for economic co-operation and development is to promote policies that will improve the economic and social well being of people around the world. >> 2 0 obj Pharmaceuticals have contributed to improvements in life expectancy and quality of life of many patients. /Gamma [1.8 1.8 1.8] DRAFT OECD GUIDELINE FOR THE TESTING OF CHEMICALS Test Guideline 452: Chronic Toxicity Studies INTRODUCTION 1. These initial phase residue guidelines emphasize laboratory or contained studies, while the guidance documents emphasize technical policy frameworks for their use. These initial phase residue guidelines emphasize laboratory or contained studies, while the guidance documents emphasize technical policy frameworks for their use. /Filter /LZWDecode 402 Adopted: OECD GUIDELINE FOR TESTING OF CHEMICALS 24 Feb 1987 "Acute Dermal Toxicity" 1. %���� If sublethal effects are observed (see paragraph 20), these should be recorded. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical … ����P��1B The original Guideline 420 was adopted in July 1992 as the 1. 1. �&�Áp�r �!�X�P����"��^G)��1��"���c���H�b0h�A�/��(�jE:�]*����J)�F� ��{!��d�Րe>��!��RT5A ��T01���6��\4����a���9�®"� ��p:L����-� ��ap�q>"J.��� s�΂��0e6���(H�r8��b��:�Ά�1 �80�ɥ�d�^1�/��EÑ�V)���G8�`6�­vцJq���T* ֒��� @#�/���H�"��H�"�a ����|$@�J} /Width 736 The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. 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