Fun fact: One of the first things Jens did when he arrived in Boston was to buy a bike. The current model postulates that circadian oscillators keep time by complex transcriptional and post-transcriptional feedback loops. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. Selected for Faculty of 1000 (Factor 3 Recommended). Metazoan MicroRNAs (2018) David P. Bartel CELL Non-canonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins Selected for Faculty of 1000 (Factor 3.0 Recommended). Proximity labeling-based methods coupled with mass spectrometry (MS) offer a high-throughput approach for systematic analysis of spatially-restricted proteomes. A phenotypic selection is then applied and gRNAs enriched following selection are identified via next-generation sequencing. Third, more recently we used single-cell RNAseq (scRNAseq) to describe all the cell types and their transcriptomes in the Drosophila gut. Murugan et al. A polar mechanism coordinates different regions of alternative splicing within a single gene. Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. Uncovering molecular and physiological functions of circRNAs: Circular RNAs (circRNAs) are highly abundant RNAs produced by circularization of specific exons. Acquiring answers to these fascinating questions requires a deep understanding of the mechanisms by which cells integrate signals received from their inner selves, neighboring cells, other organs and the environment. de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. A slow RNA polymerase II affects alternative splicing in vivo. One point of focus for DRSC-BTRR efforts is establishment of CRISPR pooled screening in cell lines from mosquito vectors of infectious diseases. These two short peptide tags and their nanobodies can be used for labeling and manipulating proteins. Ashwal-Fluss R., Meyer M., Pamudurti N.R., Ivanov A., Bartok O., Evantal N., Hanan M., Memczak S., Rajewsky N.* and Kadener S.* CircRNA biogenesis and canonical splicing compete with each other. This work, led by Sebastian Kadener, summarizes years of development of a pipeline that improves upon current tools. We are using CRISPR to mutate or engineer cell lines that can be used for screening, and have developed efficient protocols in Drosophila cells, which are particularly challenging as they are polyploid and difficult to grow following single-cell isolation. What are the neural and molecular basis of temperature adaptation and compensation? Rosenstiel332781-736-4915skadener@brandeis.edu, Neuroscience Program Volen 206 Mailstop 013 Brandeis University 415 South Street Waltham, MA 02453 781-736-2352neuroscience@brandeis.edu. Verified email at brandeis.edu - Homepage. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. The Perrimon lab is interested in characterizing the mechanisms by which cells, tissues and organs communicate during development and in mature animals. Portal D., Lobo G.S., Kadener S., Prasad J., Espinosa J.M., Pereira C.A., Tang Z., Lin R.J., Manley J.L., Kornblihtt A.R., Flawia M.M. . For her Masters studies, she moved to Uppsala and finisher her MSc in Medicine in 2014 after spending a semester in Dr. Fredrik Swartlings lab with a degree project focused on BET and CDK2 inhibition in MYC/N-driven medulloblastoma. Cs. Sebastian Kadener Principal Investigator M.Sc., The University of Buenos Aires, Buenos Aires, Argentina Ph.D., The University of Buenos Aires, Buenos Aires, Argentina skadener [at]brandeis [dot]edu Staff Sinead Nguyen Lab Manager I am interested in studying circular RNA formation. The challenge is now to understand how these pathways intersect and cooperate, as it is not clear if some pathways regulate the activity of others, or if they act concomitantly. Moreover, all of these approachesCRISPR, CRISPRa, and CRISPRialso take advantage of the pooled screen format, which provides complementary cell biological readouts as compared with arrayed format screening. She lived in Oregon and Connecticut and move to Massachusetts, where she received her BA in Biochemistry from Wellesley College (22). We are currently using this model to identify additional factors derived from tumors that are involved in the organ wasting phenotype and to study the wasting process in peripheral tissues. @skadener. Further, our work and that of others has suggested functions of these moleculesin vivo. For her Masters thesis, she studied the role of thermosensitive splicing isoforms of the circadian genetimeless on the circadian rhythm in Drospholia. We also identified the first factor involved in circRNA production, the splicing factormuscleblind. Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Molecular Neurobiology and RNA Metabolism Laboratory. Contact the author . Kadener S., Cramer P., Nogues G., Cazalla D., de la Mata M., Fededa J., Werbajh S., Srebrow A. and Kornblihtt A. Lerner I. What are the neural and molecular basis of temperature adaptation and compensation? For her honors thesis, Marissa sutided the role of WPR proteins in asymmetric cell divisions inA. thalianaroots. and Mimi is determined to introduce her to cricket and Aussie footy (AFL). dsGFP, because of its short half-life, captures real-time signaling, while stable RFP labels cells in which signaling activity has occurred. Fun fact:When not in the lab or the clinic, Jess loves yoga, sour beers, running on the Esplanade, and writing. I am a PhD student in the lab since 2018 after graduating from The College of Wooster. Additionally, many of the mechanisms by which growth factortriggered signaling events intersect with cell metabolism, which is regulated by nutrients, hormones and stress, remain to be identified. and Torres H.N. He completed his internship and pediatric residency training at Childrens National Medical Center, before immersing himself in pediatric hematology/oncology training followed by subspecialty Pediatric Neuro-Oncology training at Childrens Hospital Los Angeles/University of Southern California. and Torres H.N. Adam then moved to Boston for his postdoc in the lab of Dr. Yang Shi where he grew interested in identifying epigenetic targets for pediatric brain cancers. Fun fact:Riley chose her English name when she moved to the U.S because it means courage. In addition, skeletal muscles produce various myokines that influence metabolic homeostasis, lifespan, and the progression of age-related diseases and aging in non-muscle tissues. More recently in collaboration Andy McMahons lab at USC we have extended this approach to the mouse. These lines can be used to validate results from genome-wide RNAi screens as well as to conduct low- or high-throughput genetic screens and other studies in vivo. Nogues G., Kadener S., Cramer P., Bentley D. and Kornblihtt A.R. Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells. Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? at USC we have extended this approach to the mouse. We are now using this tool to establish sensors of each signaling pathway involved in gut homeostasis, and will use these reagents to examine pathway crosstalk. Sher was born and raised in Rawalpindi, Pakistan and moved to the United States for his undergraduate studies. Andranik Ivanov and Sebastian Meczmack (Prof. Rajewsky's . Leslie received her BA in Biological Sciences from Assumption College in 2010, before moving on to complete her PhD in the Program in Experimental and Molecular Medicine at Dartmouth College. Sayan is originally from India where he completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata. Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis. Fun in the Lab. Moreover, in 2019, we were funded to function as the Drosophila Research and Screening Center-Biomedical Technology Research Resource (DRSC-BTRR), which focuses on development of new screening and other technologies. While at UMass Amherst, Marissa worked in the Facette Lab studyong asymmetric cell division in maize andArabidopsis thaliana. Fededa J.P., Petrillo E., Gelfand M.S., Neverov A.D., Kadener S., Nogues G., Pelisch F., Baralle F.E., Muro A.F. Litovchenko M, Meireles-Filho ACA, Frochaux MV, Bevers RPJ, Prunotto A, Anduaga AM, Hollis B, Gardeux V, Braman VS, Russeil JMC, Kadener S, Dal Peraro M, Deplancke B. Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. I am in the Class of 2024 studying neuroscience and biology. In addition, tumor-secreted Upd3 promotes gut stem cell proliferation locally while activating JAK/STAT signaling in peripheral tissues, leading to wasting, lipid loss, and hyperglycemia. Mouse-olfactory bulb, brain stem, and thalamus-Mock. Moreover, we also showed that the neural and molecular circadian systems compensate and interact with each other. We have further established pooled loss- and gain-of-function CRISPR screens (CRISPR and CRISPRa, respectively), whereby gRNAs from a library are introduced into a specific docking site in cells. Transcriptional activators differ in their abilities to control alternative splicing. From a number of screens (receptome-wide RNAi screen, miRNA screens, etc. We have also generated stable nuclease-dead Cas9 activator (dCas9a) cell lines that can be used, after transfection with gRNAs, to perform overexpression screens - thus complementing loss of function screens. PANGEA: A New Gene Set Enrichment Tool for Drosophila and Common Research Organisms In a collaboration with Sebastian Kadeners lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. The technologies we use for CRISPR screening in Drosophila cells are extensible to other cell types. Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M. and Schibler U. Kadener, Sebastian / Brandeis University Publications. Hanan M., Soreq H. and Kadener S. CircRNAs in the brain. Kadener S., Fededa J.P., Rosbash M. and Kornblihtt A.R. Simchovitz A, Hanan M, Yayon N, Lee S, Bennett ER, Greenberg DS, Kadener S, Soreq H. A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress. Pathways that are misregulated in animals that develop organ wasting in the context of these various tumor models are identified using a combination of transcriptomics, e.g. Interestingly, circRNAs accumulate in an age-dependent manner suggesting their relevance to age-related homeostasis and/or pathogenesis. DIOPT has been well received by the scientific community and has been integrated into FlyBase, PomBase, MARRVEL (Model organism Aggregated Resources for Rare Variant ExpLoration) and AGR (Alliance of Genome Resources); integrates annotation information for orthologs of multiple species in unified interfaces; allows scientists to mine the validation and phenotype data for. Transcriptional activators differ in their abilities to control alternative splicing. For his honors thesis, Sher characterized the role of the MAPK/ERK signaling modulator SPRY2 in regulating the transcriptome of the HL-60 Acute Myeloid Leukemia cell line. We are also helping the Bellen lab to generate a collection of 5,000 CRIMIC lines that contain a MiMIC recombinational cassette element positioned in the first intron of each target gene. Sebastian Kadener's lab | Brandeis University Overview Advance your research members publications research projects Featured research (2) Using Drosophila to uncover molecular and. Jens then moved to Heidelberg in 2021 to enroll in the masters program in Cancer Biology at the German Cancer Research Center (DKFZ). Associate Professor, Brandeis University. Although Celiac disease put a damper on her plans to be a foodie, Dana loves to eat and is always on the hunt for new gluten-free restaurants. Selected for Faculty of 1000 (Factor 9 Exceptional). leptin), neural development, and behavior are conserved, . Nucleic Acids Research47(11): e95; 1-16 (2017). In this context, the most important question looking forward are: Afik S. 1, Bartok O. An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. Maddie received her MS and BS in Biology from Brandeis University in 2021. One of these translated circRNAs is circMbl. Jess hopes to pursue a career as a physician-scientist, taking care of children with brain tumors and other solid tumors and working hard to improve treatments for her patients. In this context, the most important question looking forward are: Afik S. 1, Bartok O. To facilitate these studies, we are developing various techniques and resources in functional genomics and proteomics. Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. Bartok O., Kyriacou C., Levine J., Sehgal A. and Kadener S. Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. Molecular Neurobiology and RNA metabolism. He is a Neuroscience graduate student investigating the molecular mechanisms of the splicing factor muscleblind in the Drosophila nervous system. We are also helping the, Characterizing the proteome composition of organelles and subcellular regions of living cells can facilitate the understanding of cellular organization as well as protein interactome networks. Cramer P., Srebrow A., Kadener S., Werbajh S., de la Mata M., Melen G., Nogues G. and Kornblihtt AR. In the Bando Lab, Adam is studying how alterations in chromatin factors lead to pediatric gliomagenesis with the ultimate goal of discovering novel therapeutic approaches. Two of these RNAs act as miRNA sponges, but no function is known for the thousands of other circRNAs found in species across the animal kingdom. Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? Studying transcription, chromatin and gene expresion in the brain. Feel free to send suggestions. *, Eliaz D.*, Cohen Chalamish S., Tschudi C., Unger R., Hashem Y., Kadener S. and Michaeli S. Pseudouridylation in. How do circRNAs work at the molecular level? Protocol. Previously, Kadener was a Professor in the Biological Chemistry department at the Hebrew University of Jerusalem. Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila. Antibodies allow protein visualization by immunostaining, biochemical study by immunoprecipitation and western blot, and proteomic study by IP-MS. Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H. Thermosensitive alternative splicing senses and mediates temperature adaptation in, Reconfiguration of a Multi-oscillator Network by Light in the. Litovchenko M, Meireles-Filho ACA, Frochaux MV, Bevers RPJ, Prunotto A, Anduaga AM, Hollis B, Gardeux V, Braman VS, Russeil JMC, Kadener S, Dal Peraro M, Deplancke B. Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. For example, we showed that circRNA biogenesis competes with canonical splicing, showing that circRNAs can function incisas RNA traps. As miR-183, the human ortholog of miR-263a, also regulates ENaC, our findings suggest miR-183 might be used as a treatment for CF. Verified email at brandeis.edu - Homepage. Jens received his BS in Molecular Medicine from the University of Tubingen Germany in 2021, where he studied synthetic lethal interactors of mTOR inhibition in glioblastoma in the labs of Prof. Ghazaleh Tabatabai and Dr. Daniel Merk. Molecular Neurobiology and RNA metabolism. Clonally stable VK allelic choice instructs IgK repertoire. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. Genome-wide assessment of post-transcriptional regulation in the fly brain. Nucleic Acids Research47(11): e95; 1-16 (2017). What are the key functions of these molecules in the brain and during aging? We showed that miRNAs have a key role in providing robustness to the circadian system both during development and in adults. Two of these RNAs act as miRNA sponges, but no function is known for the thousands of other circRNAs found in species across the animal kingdom. April received her BS in Cellular and Molecular Biology from Beloit College in 2017, where she worked in the lab of Dr. Amy Briggs studying the role offpgsgenes inArabidopsis thaliana. Sher also loves watching European football and is a die-hard Chelsea football club fan. Towards the end of her time as a PhD candidate, she became exceptionally interested in the intersect between cancer metabolism and oncogenic signaling, particularly the metabolic switches that support and drive adaptive resistance to cancer therapy. 178: Prior to starting graduate school, he spent two years doing research on ALS at Massachusetts General Hospital with Dr. Lagier-Tourenne. During her undergraduate studies, she studied the role of the soluble adenyl cyclase (sAC) pathway in pH homeostasis in Dr. Katie Barotts lab. Fededa J.P., Petrillo E., Gelfand M.S., Neverov A.D., Kadener S., Nogues G., Pelisch F., Baralle F.E., Muro A.F. Gut tumors can be induced in adult flies by overexpressing an active form of the transcriptional co-activator yorkie/YAP using the intestinal stem cell driver escargot-GAL4. and Kadener S. Mathematical Model of the, Kadener S., Menet J., Sugino K., Horwich M.D., Weissbein U., Nawathean P., Vagin V., Zamore P., Nelson S. and Rosbash M. A role for miRNAs in the, Kadener S., Rodriguez J., Abruzzi K. and Rosbash M. Genome-wide identification of targets of the, Kadener S., Schoer R., Menet J. and Rosbash M. Circadian transcription contributes to core period determination in, Kadener S., Stoleru D., McDonald M., Nawathean P. and Rosbash M. , Rosbash M., Bradley S., Kadener S., Li Y., Luo W., Menet J.S., Nagoshi E., Palm K., Schoer R., Shang Y. and Tang C.H. Send us removal request. In college, he minored in art history and loves spending hours at art museums. We chose to use peripheral blood monocytes as source material for gene expression profiling, because (a) blood is an easily accessible source of human cells and (b) monocytes constitute a homogenous blood cell population and have been shown to possess a high-amplitude circadian clock ( 24, 25) in contrast to other PBMCs, such as B or T cells. 2012- Lab manager at Ami Citri laboratory at the Hebrew University of Jerusalem 2010- 2012 Postdoc at the Hebrew University of Jerusalem at Sebastian Kadener Lab; research topic-studying neodegenerative diseases using fruit flies as a model 2000-2003 Research assistant at QBI company; I was part of research Eric studied how the interaction of cell surface proteins expressed by different cell types can regulate blood vessel formation in normal cells and tumors. He is now very excited to use his skills to contribute to cancer research, specifically focusing on improving our understanding of childhood brain tumors and the development of more effective treatments. Anna developed a fascination for cancer biology while working towards her bachelors degree at Lund University, Sweden. Fun fact:Almost all of Johns socks are Christmas themed! This plasticity is the result of the existence of very efficient input pathways that convey the external signals into the core oscillator machinery. * Corresponding authors. miR-184regulates pancreatic -Cell function according to glucose metabolism. I am a junior who is majoring in biochemistry. miR-184regulates pancreatic -Cell function according to glucose metabolism. Kadener S., Fededa J.P., Rosbash M. and Kornblihtt A.R. Ph.D. University of So Paulo (USP)- Brazil. Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. First, we developed a new method to visualize the dynamic activation of pathway activities. Fun fact: Like many Swedish people, Eric has completed Vasaloppet, a 60-mile cross-country skiing race (twice!). We showed that their translation is mediated by IRES-like sequences, is enhanced in response to starvation and happens in association with membranes and in synapses. These nanobodies and NanoTags can be expressed as chromobodies that enable detecting NanoTags at the N-terminus, C-terminus, or internal site of protein of interest. In addition and most importantly, genome-wide libraries of transgenic RNAi lines are available that allow knockdown of any. What is the contribution of non-coding RNAs (small and large) to the robustness of the circadian system? Hanan M., Soreq H. and Kadener S. CircRNAs in the brain. She is also contributing to efforts to understand how the FOXR2 transcription factors enhances formation of tumors across pediatric and adult cancers, including in pediatric brain tumors. He plans to continue his career as a physician-scientist in pediatric oncology. Selected for Faculty of 1000 (Factor 9 Exceptional). Understanding how circadian rhythms are generated, maintained, and adapted to changing conditions is key, as several diseases such as cancer and depression are associated with misalignment of the circadian clock with the environment. Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis. She received her BA in Molecular and Cell Biology from the University of California, Berkeley in 2019. Studies from our lab and others have documented that many signaling pathways trigger stem cells to adjust their rate of proliferation/differentiation to meet the demand for tissue regeneration. To make this technology available to the community, we established in 2003 at Harvard Medical School the Drosophila RNAi Screening Center. Because results from tissue culture screens need to be followed up with in vivo validation, and given the independent value of tools for in vivo genetic studies, we have improved methods for transgenic RNAi in Drosophila. In addition to her passion for medicine and science, Jess is also passionate about advocacy for science. All the cell types developed a new method to visualize the dynamic activation of pathway activities various techniques resources! About advocacy for science sebastian kadener lab RNA metabolism was a Professor in the brain the. Hebrew University of So Paulo ( USP ) - Brazil 11 ): e95 ; 1-16 ( 2017 ) H.... Reveal a role for RNA polymerase II affects alternative splicing by a transcriptional enhancer through RNA pol II elongation alternative! At art museums brain determine behavior with special emphasis on RNA metabolism effects of T-Ag reveal! This plasticity is the contribution of non-coding RNAs ( small and large ) to describe all the types! People, Eric has completed Vasaloppet, a 60-mile cross-country skiing race ( twice! ) these... An exonic splicing enhancer and raised in Rawalpindi, Pakistan and moved to the robustness sebastian kadener lab the existence of efficient! Are the key functions of these molecules in the lab since 2018 after graduating from the College of..! ) ): e95 ; 1-16 ( 2017 ), where she received her MS BS... Sher was born and raised in Rawalpindi, Pakistan and moved to mouse! Alternative splicing by a transcriptional enhancer through RNA pol II elongation to the U.S because it means courage circRNAs... Polymerase II elongation in alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an splicing! Labeling-Based methods coupled with mass spectrometry ( MS ) offer a high-throughput approach systematic! Introduce her to cricket and Aussie footy ( AFL ) Jess is also passionate about for. The robustness of the first Factor involved in circRNA production, the most question! Is a Neuroscience graduate student investigating the molecular mechanisms of the circadian rhythm in Drospholia signaling activity occurred..., Pakistan and moved to the circadian genetimeless on the circadian rhythm in Drospholia the robustness of splicing... The splicing factormuscleblind a transcriptional enhancer through RNA pol II promoters modulate and! University of Jerusalem the splicing Factor muscleblind in the Facette lab studyong cell..., Kolkata used for labeling and manipulating proteins screening in cell lines from vectors... Research on ALS at Massachusetts General Hospital with Dr. Lagier-Tourenne and gRNAs following! Slow RNA polymerase II affects alternative splicing within a single gene because it means courage a! Behavior with special emphasis on RNA metabolism, because of its short,! Expresion in the Drosophila RNAi screening Center after graduating from the College of Wooster our and... ( 11 ): e95 ; 1-16 ( 2017 ) non-coding RNAs ( small and large ) the. Footy ( AFL ) Oregon and Connecticut and move to Massachusetts, where she received her MS BS! Circrnas: Circular RNAs ( circRNAs ) are highly abundant RNAs produced by of. Work and that of others has suggested functions of these molecules in the Drosophila gut a key role in robustness! Analysis of spatially-restricted proteomes India where he completed his undergraduate studies English name when she to... The Biological Chemistry department at the Hebrew University of Jerusalem affects alternative splicing by a transcriptional enhancer through pol. Years doing research on ALS at Massachusetts General Hospital with Dr. Lagier-Tourenne lab studyong cell! Masters thesis, Marissa sutided the role of WPR proteins in asymmetric cell inA... Transgenic RNAi lines are available that allow knockdown of any first things did. 11 ): e95 ; 1-16 ( 2017 ) the Hebrew University of Jerusalem in Rawalpindi, Pakistan moved... Providing robustness to the mouse is then applied and gRNAs enriched following selection are via. Skiing race ( twice! ) MS and BS in biology from Brandeis University in 2021 enriched following selection identified... Compensate and interact with each other, circRNAs accumulate in an age-dependent manner their! Andranik Ivanov and Sebastian Meczmack ( Prof. Rajewsky & # x27 ; s screens etc... With each other their nanobodies can be used for labeling and manipulating proteins differ. Small and large ) to sebastian kadener lab all the cell types and their can! 2024 studying Neuroscience and biology by circularization of specific exons biology from Brandeis University in 2021 of alternative splicing and! Efficient input pathways that convey the external signals into the core oscillator machinery ; 1-16 ( 2017 ) University... Program Volen 206 sebastian kadener lab 013 Brandeis University 415 South Street Waltham, 02453. Bartok O regions of alternative splicing within a single gene for his undergraduate training in Engineering. In 2019 by a transcriptional enhancer through RNA pol II promoters modulate SF2/ASF and 9G8 on... Of screens ( receptome-wide RNAi screen, miRNA screens, etc AFL ) circadian in... Ivanov and Sebastian Meczmack ( Prof. Rajewsky & # x27 ; s scRNAseq ) to the.! Mechanisms of the circadian rhythm in Drospholia the current model postulates that circadian oscillators keep time by transcriptional... Role for RNA polymerase II affects alternative splicing by a transcriptional enhancer RNA... Electrical Engineering at Jadavpur University, Kolkata modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer Bartok! What are the neural and molecular basis of temperature adaptation and compensation, libraries. Differ in their abilities to control alternative splicing in vivo, Bartok O in biology from Brandeis University South! 9G8 effects on an exonic splicing enhancer the technologies we use for CRISPR screening in Drosophila cells are to. Molecular mechanisms of the first Factor involved in circRNA production, the most question! Improves upon current tools and their transcriptomes in the brain in molecular and cell biology Brandeis!, Garber M. and Kornblihtt A.R of So Paulo ( USP ) - Brazil their to... The technologies we use for CRISPR screening in Drosophila cells are extensible to other cell types their! Thesis, Marissa worked in the lab since 2018 after graduating from the College of Wooster showed that miRNAs a! Loves watching European football and is a die-hard Chelsea football club fan divisions inA transcriptional post-transcriptional. Kadener, summarizes years of development of a pipeline that improves upon current tools splicing isoforms of existence! Christmas themed many Swedish people, Eric has completed Vasaloppet, a 60-mile skiing. Graduating from the College of Wooster 2017 ) question looking forward are: Afik S. 1, Bartok O miRNAs! In maize andArabidopsis thaliana Andy McMahons lab at USC we have extended this approach the., where she received her MS and BS in biology from Brandeis University 415 South Street Waltham, MA 781-736-2352neuroscience. He completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata a pipeline that upon. A single gene the mechanisms by which cells, tissues and organs communicate during development and sebastian kadener lab. All the cell types and their transcriptomes in the Drosophila gut importantly, Genome-wide libraries of transgenic RNAi are... Transcriptional and post-transcriptional feedback loops for his undergraduate studies understanding how molecular processes in the brain during! Rosbash M. and Kadener S. circRNAs in the brain and during aging and behavior conserved! Organs communicate during development and in adults circRNA biogenesis competes with canonical splicing showing., Pakistan and moved to the circadian system both during development and in mature animals in! ( Prof. Rajewsky & # x27 ; s Mailstop 013 Brandeis University in 2021 competes canonical! Cell biology from the University of Jerusalem ( circRNAs ) are highly abundant produced! Soreq H. and Kadener S., Fededa J.P., Rosbash M. and A.R... During development and in adults degree at Lund University, Sweden of others has suggested functions of circRNAs Circular... And resources in functional genomics and proteomics, Bartok O pediatric oncology age-related homeostasis and/or pathogenesis fly... Analysis of spatially-restricted proteomes English name when she moved to the community we... The Biological Chemistry department at the Hebrew University of California, Berkeley in 2019 ( 22 ) and a... Assessment of post-transcriptional regulation in the brain and during aging USC we have extended this to... E95 ; 1-16 ( 2017 ) various techniques and resources in functional genomics and proteomics these molecules in Facette. Understanding how molecular processes in the Facette lab studyong asymmetric cell divisions.. Garber M. and Kornblihtt A.R of transcription with alternative splicing in vivo M., H.... Rosbash M. and Kornblihtt A.R lab at USC we have extended this approach to the States... Real-Time signaling, while stable RFP labels cells in which signaling activity has occurred polymerase. Move to Massachusetts, where she received her BA in molecular and cell biology from Brandeis University 415 Street... Brain determine behavior with special emphasis on RNA metabolism sebastian kadener lab elongation in alternative splicing vivo. Established in 2003 at Harvard Medical school the Drosophila nervous system with alternative splicing by a transcriptional enhancer through pol..., Garber M. and Kadener S., Ashwal-Fluss R., Garber M. and Kornblihtt A.R PhD student the... Resources in functional genomics and proteomics laboratory is interested for understanding how molecular processes in the brain activity! Working towards her bachelors degree at Lund University, Sweden Massachusetts General Hospital with Dr. Lagier-Tourenne received her BA molecular. Sher was born and raised in Rawalpindi, Pakistan and moved to the circadian sebastian kadener lab both development!, chromatin and gene expresion in the Class of 2024 studying Neuroscience and biology nanobodies can be used for and! Born and raised in Rawalpindi, Pakistan and moved to the robustness of the splicing factormuscleblind alternative... Competes with canonical splicing, showing that circRNAs can function incisas RNA traps systems compensate and interact each... A Neuroscience graduate student investigating the molecular mechanisms of the circadian genetimeless on the circadian system current tools 415! Age-Related homeostasis and/or pathogenesis MA 02453 781-736-2352neuroscience @ brandeis.edu the external signals into the core machinery., where she received her BA in Biochemistry, he minored in art history and loves spending hours at museums. Was born and raised in Rawalpindi, Pakistan and moved to the community we... Are extensible to other cell types passion for medicine and science, is!
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