Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01124929. Patients with HIV and AIDS may have another systemic opportunistic infections including GI infections like cryptosporidiosis, Microsporidiosis or isosporiasis. Diagnosis & Treatment of Abdominal Tuberculosis Diagnosis of abdominal tuberculosis is often clinical, but is confirmed with tests (blood test and other investigations). Get the latest research information from NIH: You have reached the maximum number of saved studies (100). In a randomized controlled trial, Balasubramaniam et al reported no difference in success rate of 6mo (99%) vs 12 months (94%) antituberculous drugs (conventional strategy) in the treatment of abdominal tuberculosis. Although Directly Observed Therapy (DOTs) have been proved to be effective in patients with pulmonary tuberculosis, lymph nodal tuberculosis, however, there is a lack of data on efficacy of DOTS in other extra-pulmonary disease including abdominal tuberculosis. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Clin Infect Dis. Risk factors for development of abdominal TB include cirrhosis, HIV infection, diabetes mellitus, underlying malignancy, treatment with anti-tumor necrosis factor (TNF) agents, and use of peritoneal dialysis [ 6-10 ]. Abdominal TB is generally responsive to medical treatment, and early diagnosis and management can prevent unnecessary surgical intervention. In a randomized controlled trial, Balasubramaniam et al reported no difference in success rate of 6mo (99%) vs 12 months (94%) antituberculous drugs (conventional strategy) in the treatment of abdominal tuberculosis. In most of the reports it is said to account for more than 10% of the EPTB cases. Response to treatment (after 6 months and nine months of RNTCP Category I treatment) [ Time Frame: 1 year ], Recurrence of symptoms of abdominal tuberculosis (intestinal and peritoneal) after 1 year of follow up in those who receive 6 months or 9 months of Cat I treatment [ Time Frame: 1 year ], Newly diagnosed patients with Intestinal TB or Peritoneal TB, Has not received ATT for Tuberculosis any where in the body during past 5 years. Therefore, assessment of response to anti-tuberculosis therapy may be blurred. Despite these recommendations, most physicians treating abdominal tuberculosis use antituberculous therapy for 9 months, sometimes even 12 months without any scientific justification. Hypothesis There may not be a significant difference in the efficacy and recurrence rate of abdominal tuberculosis in those treated for six months vs those treated for 9 months with intermittent short course category I regimen under RNTCP. Treatment of Abdominal Tuberculosis is quite complex and the course of treatment is normally for about a year. Patients having good general health and not too sick. [2006] 1.3.7.10 Do not offer anti‑TB treatment dosing regimens of fewer than 3 times per week. Choosing to participate in a study is an important personal decision. Most current guidelines recommend treating people that have abdominal TB with antituberculous treatment (ATT) for six months, but some clinicians treat for longer periods due to concerns that six months is not adequate to achieve cure and prevent relapse of the disease after the end of treatment. Read our, ClinicalTrials.gov Identifier: NCT01124929, Interventional COVID-19 is an emerging, rapidly evolving situation. [2006, amended 2016] Talk with your doctor and family members or friends about deciding to join a study. We, therefore planned to conduct a multicenter randomized controlled trial to determine the difference in the efficacy and recurrence rate in 6months and 9 months of intermittent short course category I regimen under RNTCP. Although DOTS have been proved to be effective in patients with pulmonary tuberculosis, lymph nodal tuberculosis, however, there is a lack of data on efficacy of DOTS in other extra-pulmonary disease including abdominal tuberculosis. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. In order to keep the study group homogenous for comparison, we plan to exclude all those with HIV infection, Patients must not been used investigational agents during the past 6 months. Rationale Most of the guidelines on the treatment of tuberculosis suggest that 6 months treatment is sufficient for extrapulmonary tuberculosis except for bone tuberculosis and tubercular meningitis. Please remove one or more studies before adding more. There may be an overlap of GI manifestations such as diarrhea, abdominal pain, anemia, fever. Abdominal TB is one of the common forms of extrapulmonary Tuberculosis (EPTB). Of all the EPTB cases, abdominal tuberculosis could be the third most common form after pleural effusion and lymph nodal disease. 1.3.7.9 Use fixed‑dose combination tablets as part of any TB treatment regimen. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. The symptoms of tuberculosis (TB) vary depending on which part of the body is affected. Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Why Should I Register and Submit Results?

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