To do that, they used a harmless virus to insert the genes into the eggs, a process that has already been done in other mammals including mice, pigs, sheep and marmoset monkeys. For the team, which included collaborators in Japan, the trick was to get the monkey gene for the restriction factor - known as TRIMCyp - into cats to block cells from becoming infected with the virus. In 2008, TODAY reported that Audubon Nature Institute scientists were able to engineer an orange tabby cat to glow fluorescent green in the darkness. ... known as feline immunodeficiency virus (FIV) - in these cats. So, the finding that it's possible to insert protective genes -- though in cats -- is also a step forward for HIV research for humans, researchers said. Part of HuffPost Wellness. Tests on cells taken from the cats show they are resistant to feline immunodeficiency virus, or FIV, which causes Aids in cats. The team has mated two of the three original green-glowing cats, which have produced litters totalling eight kittens which make glowing cells as well. The disease is called Feline Immunodeficiency Virus, or FIV. Researchers were able to do this by inserting a monkey gene into feline eggs before they were fertilized with sperm. The purpose of that experiment was to see if they could successfully perform gene implantation. "This provides the unprecedented capability to study the effects of giving Aids-protection genes into an Aids-vulnerable animal," Dr Eric Poeschla of the Mayo Clinic in Rochester, Minnesota, who led the study, said.Poeschla said that besides people, cats and to some extent, chimpanzees, were the only mammals that develop a naturally occurring virus that causes Aids. FIV infects mostly feral cats, of which there are half billion in the world, Poeschla said. Board Rules 1. "We haven't shown cats that are AIDS-proof," study researcher Eric Poeschla, a molecular biologist and infectious disease specialist at the Mayo Clinic College of Medicine, told LiveScience. "This technology can be applied to a wide range of species, for many of which there are clear applications and potential benefits," Dr Laurence Tiley of the University of Cambridge said.So far, Poeschla's team has only tested cells taken from the animals and found they were resistant to FIV. The scientists also inserted jellyfish genes that make the modified cells glow an eerie green colour - making the altered genes easy to spot. But eventually they plan to expose the cats to the virus and see if they are protected. That the protection gene is expressed in the cat lymphoid organs, where AIDS virus spread and cell death mostly play out, is encouraging to us, however.". For cats, this may eventually lead to gene therapy or new drug treatments for FIV, he said. ! EERIE GLOW: The cat on the right is genetically modified, the cat on the left is not. The macaque restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus's outer shield as it tries to invade a cell. Feline immunodeficiency virus (FIV) causes AIDS in cats as the human immunodeficiency virus (HIV) does in people: by depleting the body's infection-fighting T-cells. Cats and humans have a similar genetic makeup, TODAY reported. “If you could show that you confer protection to these animals, it would give us a lot of information about protecting humans,” Poeschla said. It is transmitted by biting, largely by males defending their territory, but companion cats are affected as well. Researchers said the work has several potential uses. The team engineered a jellyfish gene into the feline eggs so that they could see if the gene engineering worked -- and it did, as evidenced by the cats' ability to glow in the dark. FIV and the human immunodeficiency virus (HIV) are very similar diseases, in that they both deplete the body's own immune cells from fighting off infection. "We still have to do infection studies involving whole cats. [Figure][1] CREDIT: MAYO CLINIC Scientists have genetically modified cats by infecting their eggs with a virus containing a foreign gene—the first time this method has worked in a carnivore. Of every 100 cats in the United States, between one and three have the virus. And these defense proteins are made throughout the cat's body. Register to vote and apply for an absentee ballot today, The essential guide to taking care of your mind and body. “This technology can be applied to a wide range of species, for many of which there are clear applications and potential benefits,” Dr. Laurence Tiley of the University of Cambridge said in a statement. A Mayo Clinic team has successfully engineered cats to produce a protein that helps their bodies resist the feline immunodeficiency virus (FIV), which causes AIDS in cats. Just as the human immunodeficiency virus, or HIV, does in people, FIV works by wiping out infection-fighting T-cells. ©2020 Verizon Media. Researchers were able to do this by inserting a monkey gene into feline eggs before they were fertilized with sperm. “This provides the unprecedented capability to study the effects of giving Aids-protection genes into an Aids-vulnerable animal,” Dr. Eric Poeschla of the Mayo Clinic in Rochester, Minnesota, who led the study, said in a telephone interview. Glowing cats shed light on Aids. But certain monkey versions of these restriction factors are capable of fighting the virus and the team used one such gene from the rhesus monkey. 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